Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina.
J Physiol
; 586(18): 4393-400, 2008 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-18565994
ABSTRACT
Glaucoma is an optic neuropathy that originates with pressure-induced damage to the optic nerve. This results in the retrograde degeneration of ganglion cells in the retina, and a progressive loss of vision. Over the past several years, a number of studies have described the structural and functional changes that characterize ganglion cell degeneration in the glaucomatous eye, and following optic nerve injury. In addition, a variety of different strategies for providing neuroprotection to the injured retina have been proposed. Many of these are based on the use of brain-derived neurotrophic factor (BDNF), a particularly potent neuroprotectant in the mammalian eye and the basis of our research in this area. Of particular importance is the fact that BDNF not only promotes ganglion cell survival following damage to the optic nerve, but also helps to preserve the structural integrity of the surviving neurons, which in turn results in enhanced visual function. The studies presented here describe these attributes, and serve as the foundation for ongoing work that suggests a need to think beyond the eye in the development of future treatment strategies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nervio Óptico
/
Células Ganglionares de la Retina
/
Glaucoma
Límite:
Animals
Idioma:
En
Revista:
J Physiol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos