ATR/Mec1: coordinating fork stability and repair.
Curr Opin Cell Biol
; 21(2): 237-44, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19230642
ABSTRACT
During S phase, eukaryotic cells unwind and duplicate a tremendous amount of DNA, generating structures that are very sensitive to both endogenous and exogenous insults. The collision of DNA polymerases with damaged DNA or other obstructions to fork progression generates replication stress, which can evolve into fork collapse if the replisome components are not stabilized. To ensure genome integrity, stalled replication forks are recognized by a checkpoint, whose central player is the human kinase ATR or Mec1 in S. cerevisiae. This review will discuss recent findings revealing roles of the ATR/Mec1 kinase both in stabilizing the replisome directly and in activating the checkpoint response to regulate origin firing, DNA repair, fork restart, and cell cycle progression.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Serina-Treonina Quinasas
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Proteínas de Ciclo Celular
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Proteínas de Saccharomyces cerevisiae
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Inestabilidad Genómica
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Péptidos y Proteínas de Señalización Intracelular
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Reparación del ADN
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Replicación del ADN
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suiza