Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
Bioorg Med Chem Lett
; 19(6): 1830-4, 2009 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-19237282
ABSTRACT
A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Química Farmacéutica
/
Receptores CCR2
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos