[Association of interleukin-1B gene polymorphisms with coronary heart disease].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 40(1): 73-6, 2009 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-19292049
ABSTRACT
OBJECTIVE:
To determine whether polymorphisms in interleukin-1B gene promoter -31 and exon 5 +3953 loci are associated with coronary heart diseases (CHD) in Chengdu Han population.METHODS:
Two SNPs of IL-1B gene (+3953C/T and -31T/C) in 100 patients with CHD (CHD group) and 144 healthy controls in Chengdu were analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).RESULTS:
Two genotypes at IL-1B + 3953 locus (CC and CT) and 3 genotypes at IL-1B -31 locus (CC, TC and TT) were identified. The -31T alleles carriers were associated with a significantly increased risk of CHD as compared with the non-carriers (OR = 2.12, 95% CI 1.45-3.09, P < 0.01). Genotypes and allele frequencies at IL-1B + 3953 locus in CHD cases did not differ from the controls.CONCLUSION:
IL-1B -31T/C polymorphism may contribute to the risk of developing CHD in Chengdu Han population.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedad Coronaria
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Interleucina-1beta
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Sichuan Da Xue Xue Bao Yi Xue Ban
Año:
2009
Tipo del documento:
Article
País de afiliación:
China