CK2alpha phosphorylates BMAL1 to regulate the mammalian clock.
Nat Struct Mol Biol
; 16(4): 446-8, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19330005
ABSTRACT
Clock proteins govern circadian physiology and their function is regulated by various mechanisms. Here we demonstrate that Casein kinase (CK)-2alpha phosphorylates the core circadian regulator BMAL1. Gene silencing of CK2alpha or mutation of the highly conserved CK2-phosphorylation site in BMAL1, Ser90, result in impaired nuclear BMAL1 accumulation and disruption of clock function. Notably, phosphorylation at Ser90 follows a rhythmic pattern. These findings reveal that CK2 is an essential regulator of the mammalian circadian system.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Relojes Biológicos
/
Quinasa de la Caseína II
/
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
Idioma:
En
Revista:
Nat Struct Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón