Tolerance of a standard intact protein formula versus a partially hydrolyzed formula in healthy, term infants.
Nutr J
; 8: 27, 2009 Jun 19.
Article
en En
| MEDLINE
| ID: mdl-19545360
ABSTRACT
BACKGROUND:
Parents who perceive common infant behaviors as formula intolerance-related often switch formulas without consulting a health professional. Up to one-half of formula-fed infants experience a formula change during the first six months of life.METHODS:
The objective of this study was to assess discontinuance due to study physician-assessed formula intolerance in healthy, term infants. Infants (335) were randomized to receive either a standard intact cow milk protein formula (INTACT) or a partially hydrolyzed cow milk protein formula (PH) in a 60 day non-inferiority trial. Discontinuance due to study physician-assessed formula intolerance was the primary outcome. Secondary outcomes included number of infants who discontinued for any reason, including parent-assessed.RESULTS:
Formula intolerance between groups (INTACT, 12.3% vs. PH, 13.7%) was similar for infants who completed the study or discontinued due to study physician-assessed formula intolerance. Overall study discontinuance based on parent- vs. study physician-assessed intolerance for all infants (14.4 vs.11.1%) was significantly different (P = 0.001).CONCLUSION:
This study demonstrated no difference in infant tolerance of intact vs. partially hydrolyzed cow milk protein formulas for healthy, term infants over a 60-day feeding trial, suggesting nonstandard partially hydrolyzed formulas are not necessary as a first-choice for healthy infants. Parents frequently perceived infant behavior as formula intolerance, paralleling previous reports of unnecessary formula changes. TRIAL REGISTRATION clinicaltrials.gov NCT00666120.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hidrolisados de Proteína
/
Recién Nacido
/
Fórmulas Infantiles
/
Fenómenos Fisiológicos Nutricionales del Lactante
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
Nutr J
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos