Hepatoprotective and immunological effects of antioxidant drugs.
Tokai J Exp Clin Med
; 15(2-3): 123-7, 1990 May.
Article
en En
| MEDLINE
| ID: mdl-1983370
ABSTRACT
The hepatoprotective and immunomodulatory effects of silymarin and amino-imidazole-carboxamide-phosphate were studied in 40 patients with alcoholic cirrhosis of the liver in a one-month double-blind clinical trial. Treatment with either of the drugs normalized the elevated levels of aspartate aminotransferase, alanine aminotransferase and serum bilirubin, markedly reduced the high level of gamma-glutamyl transferase, increased lectin-induced lymphoblast transformation, decreased the percentage of OKT8+ cells and suppressed lymphocytotoxicity. None of these changes occurred in the placebo-treated group. Thus, the hepatoprotective effects of silymarin and amino-imidazole-carboxamide-phosphate in alcoholic cirrhosis can partly be attributed to the immunomodulatory activity of the drugs.
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Banco de datos:
MEDLINE
Asunto principal:
Silimarina
/
Aminoimidazol Carboxamida
/
Sistema Inmunológico
/
Hígado
/
Cirrosis Hepática Alcohólica
/
Antioxidantes
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Tokai J Exp Clin Med
Año:
1990
Tipo del documento:
Article
País de afiliación:
Hungria