Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
N Engl J Med
; 362(4): 314-9, 2010 Jan 28.
Article
en En
| MEDLINE
| ID: mdl-20107217
ABSTRACT
Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Rotavirus
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Inmunodeficiencia Combinada Grave
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Rotavirus
/
Vacunas contra Rotavirus
Tipo de estudio:
Etiology_studies
Límite:
Female
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Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
N Engl J Med
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos