Immunodominance analysis through interactions of CD8+ T cells and DCs in lymph nodes.
Math Biosci
; 225(1): 53-8, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20138186
ABSTRACT
Immunodominance is a common phenomenon observed in multiple epitopes immune systems. Previous studies hypothesize that the competition among CD8+ T cell responses against different epitopes can be used to explain immunodominance. This paper proposes a mathematical model that describes the dynamics of CD8+ T cells primed by antigen-presenting dendritic cells (DCs) in the lymph nodes, and shows that the overall avidity of the interactions between peptide-specific T cells and cognate antigen-bearing DCs may determine the immunodominance. The model suggests the probability that a peptide-specific T cell be immunodominant is proportional to (1) the cognate T cell receptor (TCR) affinity, (2) the number of complexes of cognate peptide and major histocompatibility complex (pMHC) per DC, and (3) the half-life of cognate peptide-specific pMHC. The model predicts a threshold density of pMHC complexes for T cell activation. These observations from the mathematical model are consistent with experimental studies in the open literature. For DC-based vaccine design, the model suggests a strategy of immunotherapy based on the injection of cognate antigen-pulsed DCs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Dendríticas
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Epítopos Inmunodominantes
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Modelos Inmunológicos
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Linfocitos T CD8-positivos
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Ganglios Linfáticos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Math Biosci
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos