Human CD4- 8- T cells are a distinctive immunoregulatory subset.
FASEB J
; 24(7): 2558-66, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20154266
ABSTRACT
Human CD4(-)8(-) T cells are a minor subset quantitatively but potentially important in immunity because they are predominantly distributed at body surfaces, and their number and activities increase in autoimmune diseases and decrease with aging. Distinguishing characteristics of CD4(-)8(-) T cells are found to include a unique profile of cytokines, including Serpin E1, which is not generated by other T cells, MIF, and TGF-beta. At 2-5% of the total in mixtures with CD4 + CD8 T cells, CD4(-)8(-) T cells enhance the generation of IFN-gamma and IL-17 by up to 12- and 5-fold, respectively, without contributing either cytokine or affecting cytokine production by NK/NKT cells. CD4(-)8(-) T cell-derived MIF is their major enhancer and TGFbeta their principal inhibitor of CD4 and CD8 T cell cytokine production. Decreases in CD4(-)8(-) T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos CD4
/
Subgrupos de Linfocitos T
/
Antígenos CD8
Límite:
Humans
Idioma:
En
Revista:
FASEB J
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos