African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity.
Tissue Antigens
; 76(1): 31-4, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20210923
ABSTRACT
KIR2DL1 alleles were identified by DNA sequencing of the coding region from amplified genomic DNA from 100 random African Americans. The majority of individuals (97%) carried a KIR2DL1 locus. Allele KIR2DL1*00302 was found in 68% of individuals but KIR2DL1*00401, *002, *00303, *006, and *007 were also frequent. Eleven new alleles were described KIR2DL1*00403, *01101, *01102, *012, *013N, *014, *015, *016, *017, *018, and *019. Nine of the novel alleles encoded amino acid substitutions located throughout the receptor; one allele carried a stop codon in the exon encoding the first extracellular domain.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
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Negro o Afroamericano
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Alelos
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Receptores KIR2DL1
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Frecuencia de los Genes
Límite:
Humans
Idioma:
En
Revista:
Tissue Antigens
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos