Antimicrobial central venous catheters in oncology: efficacy of a rifampicin-miconazole-releasing catheter.
Anticancer Res
; 30(4): 1353-8, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20530452
ABSTRACT
UNLABELLED Antimicrobial central venous catheters are discussed as a device to reduce catheter-related infections. Previously we have reported a study with 223 adult surgical patients randomized to receive either a rifampicin-miconazole-loaded central venous catheter (CVC) (n=118) or a standard CVC (n=105). The antimicrobial CVC was shown to reduce catheter colonization (CC) and catheter-related local infection (CRI) significantly even at long-term catheterization. Here, we present further evaluation of the study focusing on possible benefits for high-risk patients. Subgroup analyses showed a pronounced reduction of CC and CRI in male, overweight and oncology patients. Important covariates were skin colonization for CC and oncological disease for CRI. Odds ratio (OR) for reducing CC was 0.076 (95% CI 0.016-0.360) and CRI was reduced from 26% to 2.3% (p=0.001) in the cancer subgroup. Ex vivo long-term antimicrobial activity of modified catheters exceeded 4 weeks. CONCLUSION:
Immunocompromized patients suffering from cancer, transplantation, and dialysis patients with a long-term vascular access may mostly benefit from rifampicin-miconazole-releasing catheters.
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Banco de datos:
MEDLINE
Asunto principal:
Rifampin
/
Cateterismo Venoso Central
/
Materiales Biocompatibles Revestidos
/
Miconazol
/
Antibióticos Antituberculosos
/
Antifúngicos
/
Neoplasias
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania