In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
Antimicrob Agents Chemother
; 54(12): 5359-62, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-20855730
ABSTRACT
LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxazolidinonas
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2010
Tipo del documento:
Article