Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression.
BJU Int
; 108(1): 31-7, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21105986
ABSTRACT
OBJECTIVE:
⢠To assess the expression pattern of cyclooxygenase-2 (COX-2) in bilharzial and non-bilharzial related bladder cancer (BBC and NBBC) and its association with clinical outcome after radical cystectomy (RC). We also determined the clinico-pathological differences between BBC and NBBC. PATIENTS ANDMETHODS:
⢠Immunohistochemical (IHC) staining for COX-2 was performed on archival bladder specimens from 315 patients treated with RC between 1997 and 2003. ⢠Patients were divided into 2 groups Group 1 comprised 205 patients (65%) with BBC and group 2 comprised 110 patients (35%) with NBBC. ⢠Clinico-pathological differences were compared and altered IHC expression of COX-2 was correlated with clinical outcome in both groups.RESULTS:
⢠The study included 315 patients (239 males and 76 females) with median age 54 y (range 31-79) and median follow up of 63.2 months after RC. ⢠There was significant difference in histological types, tumor stage, grade, and architecture and COX-2 alterations between both groups (P < 0.05). ⢠BBC presented with lower grade, higher stage, and non-papillary non-urothelial carcinoma. COX-2 overexpression was associated with pathological T stage (P= 0.01), grade (P < 0.001) and lymphovascular invasion (LVI) (P= 0.041). ⢠COX-2 expression was an independent predictor of disease recurrence (HR 1.9, CI 0.99-3.626 and P= 0.05) and cancer specific mortality (HR 2.8, CI 1.155-6.73 and P= 0.023) only in BBC but not in NBBC (HR 1.6, CI 0.598-4.364, P= 0.344 and HR 0.349, CI 0.076-1.595, P= 0.175, respectively).CONCLUSIONS:
⢠BBC differs pathologically and biologically from NBBC. BBCs present more frequently as low-grade, high stage non-papillary and non-urothelial cancers. BBCs with COX-2 alterations are associated with worse outcome after RC. ⢠Our findings support the need for further evaluation of COX-2 and inflammatory signaling pathways as well as COX-2-targeted prevention and therapies in BC.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Schistosoma haematobium
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Neoplasias de la Vejiga Urinaria
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Esquistosomiasis Urinaria
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Carcinoma de Células Escamosas
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Biomarcadores de Tumor
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Ciclooxigenasa 2
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BJU Int
Asunto de la revista:
UROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos