Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats.
Life Sci
; 88(9-10): 392-9, 2011 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-21115020
ABSTRACT
AIMS:
The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-ß-D-manno-ß-D-gluco), (α-L-gulurono-ß-D mannurono), ß-D-gluco-ß-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rats (ZDFs). Such fibers are thought to improve glycemic control through increased GLP-1 induced insulin secretion. MAINMETHODS:
ZDFs were treated 12 weeks with normal rodent chow supplemented with cellulose (control, inert fiber), inulin or PGX® at 5% wt/wt and effects on body weight, glycemic control, and GLP-1 determined. KEYFINDINGS:
In the fed state, PGX® reduced blood glucose compared to the other groups from week 5 until study termination while insulin was significantly elevated when measured at week 9, suggesting an insulin secretagogue effect. Fasting blood glucose was similar among groups until 7-8 weeks when levels began to climb with a modest reduction caused by PGX®. An oral glucose tolerance test in fasted animals (week 11) showed no change in insulin sensitivity scores among diets, suggesting an insulinotropic effect for PGX® rather than increased insulin sensitivity. PGX® increased plasma levels of GLP-1, while HbA(1c) was markedly reduced by PGX®. Body weights were not changed despite a significant reduction in food consumption induced by PGX® up to week 8 when the PGX®-treated group showed an increase in body weight despite a continued reduction in food consumption.SIGNIFICANCE:
PGX® improved glycemic control and reduced protein glycation, most likely due to the insulin secretagogue effects of increased GLP-1.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
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Glucemia
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Diabetes Mellitus Tipo 2
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Alginatos
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Péptido 1 Similar al Glucagón
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Hiperglucemia
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Insulina
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos