The genus Actinoallomurus and some of its metabolites.
J Antibiot (Tokyo)
; 64(1): 133-9, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-21119678
ABSTRACT
In the search for novel antibiotics, natural products continue to represent a valid source of bioactive molecules. During a program aimed at identifying previously unreported taxa of actinomycetes as potential source of novel compounds, we isolated hundreds of different representatives of a new group, initially designated as 'Alpha' and independently described as Actinoallomurus. We report on a PCR-specific method for the detection of this taxon, on appropriate growth conditions and on a pilot-screening program on 78 strains. The strains produce antibacterial or antifungal compounds at a relatively high frequency. Four strains were characterized in further detail one produced the aromatic polyketide benanomicin B and its dexylosyl derivative; a second strain produced N-butylbenzenesulfonamide; a third strain was an efficient converter of soymeal isoflavonoids from soymeal constituents; and a fourth strain produced several coumermycin-related aminocoumarins, with coumermycin A2 as the major peak, and with some new congeners as minor components of the complex. These data suggest that Actinoallomurus strains possess several pathways for secondary metabolism and represent an attractive source in the search for novel antibiotics.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Actinomycetales
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ADN Bacteriano
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Reacción en Cadena de la Polimerasa
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Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2011
Tipo del documento:
Article
País de afiliación:
Italia