HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era.
Eur J Neurol
; 18(3): 527-34, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21159073
ABSTRACT
BACKGROUND AND PURPOSE:
Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse.METHODS:
Between 1996 and 2007, adult subjects without previous CNS-D within a large UK cohort were included (n=30,954). CNS-D were HIV encephalopathy (HIVe), progressive multifocal leucoencephalopathy (PML), cerebral toxoplasmosis (TOXO) and cryptococcal meningitis (CRYP). Associations between demographic, clinical and laboratory parameters with incidence and survival of CNS-D were evaluated using Poisson regression analysis and Kaplan-Meier techniques.RESULTS:
Six hundred and thirteen new CNS-D occurred in 574 subjects (HIVe187, PML113, TOXO184, CRYP129). Incidence of all CNS-D declined from 13.1 per 1000 PY in 1996/1997 to 1.0 per 1000 PY in 2006/2007 (P=0.0001). Current CD4+ cell count below 200 cells/ul and plasma HIV RNA above 100,000 copies/ml were independently associated with the development of CNS-D. Calendar year 1996/1997, older age, prior AIDS diagnosis and PML diagnosis were significantly associated with shorter survival.CONCLUSIONS:
An ongoing decline in the incidence of CNS-D has been observed in very recent years. Mortality following such a diagnosis remains high.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Complejo SIDA Demencia
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Infecciones Oportunistas Relacionadas con el SIDA
/
Terapia Antirretroviral Altamente Activa
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Neurol
Asunto de la revista:
NEUROLOGIA
Año:
2011
Tipo del documento:
Article