Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration.
J Neurosci
; 31(6): 2009-15, 2011 Feb 09.
Article
en En
| MEDLINE
| ID: mdl-21307239
ABSTRACT
The mechanisms that trigger Wallerian degeneration (WD) of peripheral nerves after injury are not well understood. During the early period of WD, fragmentation of myelin into ovoid structures occurs near the Schmidt-Lantermann incisures (SLI), a noncompact region of the myelin sheath containing autotypical adherens junction. In this study, we found that new filamentous actin polymerization occurs in the SLI of mouse sciatic nerves after injury and that its inhibition prevented not only the degradation of E-cadherin in the SLI but also myelin ovoid formation. However, the inhibition of actin polymerization could not block Schwann cell dedifferentiation. The activation of Rac GTPase was observed in the distal stump of the injured nerves, and a specific Rac inhibitor, a dominant-negative Rac, and Rac1-RNA interference blocked myelin ovoid formation. Together, these findings suggest that dynamic changes in actin in the SLI are essential for initiation of demyelination after peripheral nerve injury.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nervio Ciático
/
Degeneración Walleriana
/
Actinas
/
Polimerizacion
/
Vaina de Mielina
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Neurosci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Corea del Sur