Subclinical brain injury caused by H5N1 influenza virus infection.
J Virol
; 85(10): 5202-7, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21389133
ABSTRACT
Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Orthomyxoviridae
/
Encefalitis Viral
/
Subtipo H5N1 del Virus de la Influenza A
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón