Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion.
Br J Clin Pharmacol
; 71(4): 608-10, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21395654
ABSTRACT
AIMS:
The aim of the study was to determine the relative lung and systemic bioavailability of terbutaline.METHODS:
On separate days healthy volunteers received 500 µg terbutaline study doses either inhaled from a metered dose inhaler or swallowed as a solution with and without oral charcoal. Urine samples were provided at timed intervals post dosing.RESULTS:
Mean (SD) urinary terbutaline 0.5 h post inhalation, in 12 volunteers, with (IC) and without (I) oral charcoal and oral (O) dosing was 7.4 (2.2), 6.5 (2.1) and 0.2 (0.2) µg. I and IC were similar and both significantly greater than O (P<0.001). Urinary 24 h terbutaline post I was similar to IC + O. The method was linear and reproducible, similar to that of the urinary salbutamol method.CONCLUSIONS:
The urinary salbutamol pharmacokinetic method post inhalation applies to terbutaline. Terbutaline study doses can replace routine salbutamol during these studies when patients are studied.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terbutalina
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Agonistas de Receptores Adrenérgicos beta 2
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Egipto