[Equol induced apoptosis of human breast cancer MDA-MB-231 cell by inhibiting the expression of nuclear factor-kappaB].
Wei Sheng Yan Jiu
; 40(1): 95-8, 2011 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-21434324
ABSTRACT
OBJECTIVE:
To study the inhibition effect of equol on MDA-MB-231 cells, a human breast cancer cell line with estrogen-independent receptor.METHODS:
Cultured MDA-MB-231 cells were treated with different contents of equol. The cell viability was assessed with MTT method. The apoptosis was detected by flow cytometry and immunofluorescence. Western Blot was used to assess the expression of NF-kappaB.RESULTS:
The growth of MDA-MB-231 cells was inhibited by equol in a does-and time-dependent manner. The apoptosis of MDA-MB-231 cells induced by equol was the result of inhibiting the expression of NF-kappaB.CONCLUSION:
The apoptosis of MDA-MB-231 cells might be the reduced expression of NF-kappaB induced by equol.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
FN-kappa B
/
Apoptosis
/
Equol
Límite:
Female
/
Humans
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Asunto de la revista:
SAUDE PUBLICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China