Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets.
J Biomed Biotechnol
; 2011: 790871, 2011.
Article
en En
| MEDLINE
| ID: mdl-21541194
ABSTRACT
Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10% of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfoma Extranodal de Células NK-T
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Biomed Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
MEDICINA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia