Protective effects of broadly neutralizing immunoglobulin against homologous and heterologous equine infectious anemia virus infection in horses with severe combined immunodeficiency.
J Virol
; 85(13): 6814-8, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21543497
ABSTRACT
Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However, in vivo selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activity in vitro. Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inmunoglobulinas
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Anemia Infecciosa Equina
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Inmunodeficiencia Combinada Grave
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Virus de la Anemia Infecciosa Equina
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Anticuerpos Neutralizantes
/
Enfermedades de los Caballos
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos