Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.
Curr Opin Immunol
; 23(5): 564-72, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21865020
ABSTRACT
Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by type I interferon (IFN) and NF-κB pathways. MAVS is localized to the outer mitochondrial membrane, and has been associated with peroxisomes, the endoplasmic reticulum and autophagosomes, where it coordinates signaling events downstream of RLRs. MAVS not only plays a pivotal role in the induction of antiviral and inflammatory pathways but is also involved in the coordination of apoptotic and metabolic functions. This review summarizes recent findings related to the MAVS adapter and its essential role in the innate immune response to RNA viruses.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Virus ARN
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Virus ARN
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Factores de Transcripción
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Transducción de Señal
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Proteínas Adaptadoras Transductoras de Señales
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Inmunidad Innata
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Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Canadá