Crown ether functionalized texaphyrin monomers and dimers.
J Porphyr Phthalocyanines
; 15(7-8): 539-546, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-22025887
ABSTRACT
The synthesis and characterization of two 18-crown-6 functionalized analogues of an extensively studied gadolinium texaphyrin derivative, motexafin gadolinium (1, MGd), are reported. These are the monomeric and dimeric species, compounds 2 and 3, respectively. Both crown ether functionalized species proved to be stable at physiological pH and revealed distinct shifts in the UV spectrum when treated with sodium-, potassium-, ammonium- or zinc(II)-salts. Zinc(II) is believed to play a major role regulating apoptosis mechanisms in cancerous cells. Therefore, cytotoxicity studies of 2 and 3 were carried out using Ramos cell lines in the presence and absence of zinc(II).
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Porphyr Phthalocyanines
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos