Cellular reprogramming: a new technology frontier in pharmaceutical research.
Pharm Res
; 29(1): 35-52, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22068279
ABSTRACT
Induced pluripotent stem cells via cellular reprogramming are now finding multiple applications in the pharmaceutical research and drug development pipeline. In the pre-clinical stages, they serve as model systems for basic research on specific diseases and then as key experimental tools for testing and developing therapeutics. Here we examine the current state of cellular reprogramming technology, with a special emphasis on approaches that recapitulate previously intractable human diseases in vitro. We discuss the technical and operational challenges that must be tackled as reprogrammed cells become incorporated into routine pharmaceutical research and drug discovery.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Reprogramación Celular
/
Descubrimiento de Drogas
/
Células Madre Pluripotentes Inducidas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharm Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos