Intestinal defensin secretion in infancy is associated with the emergence of sensitization and atopic dermatitis.
Clin Exp Allergy
; 42(3): 405-11, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22093109
ABSTRACT
BACKGROUND:
Intestinal flora and innate immunity, and their interactions impact adaptive immunity.OBJECTIVE:
To study the association of fecal defensin levels in infancy with synbiotic treatment and with the emergence of atopy.METHODS:
The randomly selected group of 102 infants belonged to a randomized, double-blind placebo-controlled trial where 1223 infants in high risk for allergy received, from birth to 6 months, a mixture of synbiotics, or placebo. Clinical trials registration number for the clinical trial is NCT00298337. In the subgroup, 45 received active treatment and 56 received placebo treatment. Follow-up for the emergence of sensitization and allergic diseases lasted 5 years. At the age of 3 (n = 96) and 6 (n = 87) months, we measured fecal levels of human neutrophil peptide (HNP) 1-3 and of ß-defensin 2 (HBD2) using enzyme linked immunosorbent assays and concentrations of lactic acid bacteria on MRS agar. We used multifactorial regression in data analysis.RESULTS:
Fecal levels of HNP1-3 and HBD2 decreased from the age of 3-6 months (P < 0.0001). HBD2 levels decreased less in the synbiotics group compared with placebo (P < 0.02). High fecal HBD2 levels at 6 months were associated with an increased risk for sensitization by the age of 5 years (OR 2.5, 95% confidence interval 1.1-5.8, P < 0.03). High fecal HNP1-3 levels at 6 months were associated with a decreased risk for atopic dermatitis (OR 0.4, 95% CI 0.1-1.0, P < 0.05). Samples with very low or high HBD2 levels at 6 months had low concentrations of lactic acid bacteria (P < 0.02). CONCLUSIONS AND CLINICAL RELEVANCE Early innate immunity responses in the gut are associated with the emergence of sensitization and atopic dermatitis later in childhood.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Beta-Defensinas
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Dermatitis Atópica
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Simbióticos
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Mucosa Intestinal
Tipo de estudio:
Clinical_trials
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Pregnancy
Idioma:
En
Revista:
Clin Exp Allergy
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Finlandia