Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus.
J Nat Prod
; 75(4): 630-5, 2012 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-22360613
ABSTRACT
Breast cancer cells express ABCG2 transporters, which mediate multidrug resistance. Discovering a novel compound that can suppress ABCG2 expression and restore drug sensitivity could be the key to improving breast cancer therapeutics. In the current work, one new nor-neolignan, asperjinone (1), as well as 12 other known compounds, was isolated from Aspergillus terreus. The structure of the new isolate was determined by spectroscopic methods. Among these isolates, terrein (2) displayed strong cytotoxicity against breast cancer MCF-7 cells. Treatment with terrein (2) significantly suppressed growth of ABCG2-expressing breast cancer cells. This suppressive effect was achieved by inducing apoptosis via activating the caspase-7 pathway and inhibiting the Akt signaling pathway, which led to a decrease in ABCG2-expressing cells and a reduction in the side-population phenotype.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aspergillus
/
Lignanos
/
Transportadoras de Casetes de Unión a ATP
/
Ciclopentanos
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Proteínas de Neoplasias
/
Antineoplásicos
Límite:
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2012
Tipo del documento:
Article
País de afiliación:
China