Lack of association between rs597668 polymorphism near EXOC3L2 and late-onset Alzheimer's disease in Han Chinese.
Neurosci Lett
; 513(2): 174-7, 2012 Apr 04.
Article
en En
| MEDLINE
| ID: mdl-22381399
ABSTRACT
Recently, an international genome-wide association study (GWAS) additionally found rs597668 near EXOC3L2/BLOC1S3/MARK4 was a new genome-wide significance locus associated with late-onset Alzheimer's disease (LOAD) in Caucasians. Follow-up replication studies were conducted almost exclusively in Caucasians, and the effects of the risk locus in other populations are as yet unknown. This study investigated the GWAS-associated locus near EXOC3L2 in 1205 unrelated Northern Han Chinese subjects comprising 598 LOAD patients and 607 healthy controls matched for gender and age. The results showed no significant differences in the genotypic or allelic distributions of rs597668 polymorphism between LOAD cases and healthy controls (genotype P=0.653; allele P=0.603), even after stratification for apolipoprotein E (APOE) É4 status and statistical adjustment for age, gender and APOE É4 status. This study suggests that the rs597668 polymorphism near EXOC3L2 may not play a major role in the susceptibility to LOAD in the Northern Han Chinese population.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pueblo Asiatico
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Sitios Genéticos
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Enfermedad de Alzheimer
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Neurosci Lett
Año:
2012
Tipo del documento:
Article