The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
Antimicrob Agents Chemother
; 56(6): 3244-9, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22450967
ABSTRACT
Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an ever-increasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores Enzimáticos
/
Aminopeptidasas
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2012
Tipo del documento:
Article
País de afiliación:
Australia