Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis.
Respirology
; 17(5): 772-91, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22458269
ABSTRACT
Multidrug (MDR)- and extensively drug-resistant (XDR) tuberculosis (TB) impose a heavy toll of human suffering and social costs. Controlling drug-resistant TB is a complex global public health challenge. Basic science advances including elucidation of the genetic basis of resistance have enabled development of new assays that are transforming the diagnosis of MDR-TB. Molecular epidemiological approaches have provided new insights into the natural history of TB with important implications for drug resistance. In the future, progress in understanding Mycobacterium tuberculosis strain-specific human immune responses, integration of systems biology approaches with traditional epidemiology and insight into the biology of mycobacterial persistence have potential to be translated into new tools for diagnosis and treatment of MDR- and XDR-TB. We review recent basic sciences developments that have contributed or may contribute to improved public health response.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Salud Pública
/
Tuberculosis Resistente a Múltiples Medicamentos
/
Investigación Biomédica Traslacional
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Respirology
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos