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Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.
Cell ; 149(6): 1298-313, 2012 Jun 08.
Article en En | MEDLINE | ID: mdl-22682250
ABSTRACT
Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration. Serum C1q concentration is increased with aging, and Wnt signaling activity is augmented during aging in the serum and in multiple tissues of wild-type mice, but not in those of C1qa-deficient mice. C1q activates canonical Wnt signaling by binding to Frizzled receptors and subsequently inducing C1s-dependent cleavage of the ectodomain of Wnt coreceptor low-density lipoprotein receptor-related protein 6. Skeletal muscle regeneration in young mice is inhibited by exogenous C1q treatment, whereas aging-associated impairment of muscle regeneration is restored by C1s inhibition or C1qa gene disruption. Our findings therefore suggest the unexpected role of complement C1q in Wnt signal transduction and modulation of mammalian aging.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Complemento C1q / Vía de Señalización Wnt Límite: Animals / Humans Idioma: En Revista: Cell Año: 2012 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Complemento C1q / Vía de Señalización Wnt Límite: Animals / Humans Idioma: En Revista: Cell Año: 2012 Tipo del documento: Article País de afiliación: Japón