Prospects for prophylactic and therapeutic vaccines against hepatitis C virus.
Clin Infect Dis
; 55 Suppl 1: S25-32, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22715210
ABSTRACT
Natural cross-protective immunity is induced after spontaneous clearance of primary hepatitis C virus (HCV) infection. Although this suggests that effective prophylactic vaccines against HCV are possible, there are still several areas that require further study. Current data indicate that, at best, vaccine-induced immunity may not completely prevent HCV infection but rather prevent persistence of the virus. However, this may be an acceptable goal, because chronic persistence of the virus is the main cause of pathogenesis and the development of serious liver conditions. Therapeutic vaccine development is also highly challenging; however, strategies have been pursued in combination with current or new treatments in an effort to reduce the costs and adverse effects associated with antiviral therapy. This review summarizes the current state of HCV vaccines and the challenges faced for future development and clinical trial design.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vacunas contra Hepatitis Viral
/
Hepatitis C
/
Hepacivirus
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos