Total synthesis of (-)-FR901483.

Ma, Ai-Jun; Tu, Yong-Qiang; Peng, Jin-Bao; Dou, Qing-Yun; Hou, Si-Hua; Zhang, Fu-Min; Wang, Shao-Hua

Ma, Ai-Jun; Tu, Yong-Qiang; Peng, Jin-Bao; Dou, Qing-Yun; Hou, Si-Hua; Zhang, Fu-Min; Wang, Shao-Hua.

Afiliación

Ma AJ; State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.

Org Lett ; 14(14): 3604-7, 2012 Jul 20.

Article en En | MEDLINE | ID: mdl-22734865

ABSTRACT

ABSTRACT

A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.

Asunto(s)

Alcaloides/síntesis química; Inmunosupresores/síntesis química; Compuestos Organofosforados/síntesis química; Alcaloides/química; Estructura Molecular; Compuestos Organofosforados/química; Estereoisomerismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Alcaloides / Inmunosupresores Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2012 Tipo del documento: Article

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