Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex.
Chemistry
; 18(35): 10825-9, 2012 Aug 27.
Article
en En
| MEDLINE
| ID: mdl-22807190
ABSTRACT
Release after transmission Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Arginina
/
Terbio
/
Portadores de Fármacos
/
Péptidos de Penetración Celular
Límite:
Animals
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos