Early indicators of disease in ferrets infected with a high dose of avian influenza H5N1.
Sci Rep
; 2: 972, 2012.
Article
en En
| MEDLINE
| ID: mdl-23240077
ABSTRACT
Avian influenza viruses are widespread in birds, contagious in humans, and are categorized as low pathogenicity avian influenza or highly pathogenic avian influenza. Ferrets are susceptible to infection with avian and human influenza A and B viruses and have been widely used as a model to study pathogenicity and vaccine efficacy. In this report, the natural history of the H5N1 influenza virus A/Vietnam/1203/04 influenza infection in ferrets was examined to determine clinical and laboratory parameters that may indicate (1) the onset of disease and (2) survival. In all, twenty of 24 animals infected with 7 × 10(5) TCID(50) of A/Vietnam/1203/04 succumbed. A statistical analysis identified a combination of parameters including weight loss, nasal wash TCID(50), eosinophils, and liver enzymes such as alanine amino transferase that might possibly serve as indicators of both disease onset and challenge survival.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Orthomyxoviridae
/
Subtipo H5N1 del Virus de la Influenza A
/
Hurones
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Sci Rep
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos