The heritability of human disease: estimation, uses and abuses.
Nat Rev Genet
; 14(2): 139-49, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23329114
ABSTRACT
Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate disease heritability, how to interpret it, how biases in heritability estimates arise and how heritability relates to other measures of familial disease aggregation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido