Heterogeneous differentiation patterns of individual CD8+ T cells.
Science
; 340(6132): 635-9, 2013 May 03.
Article
en En
| MEDLINE
| ID: mdl-23493421
ABSTRACT
Upon infection, antigen-specific CD8(+) T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a uniform behavior of individual cells. We tracked the progeny of individual mouse CD8(+) T cells by in vivo lineage tracing and demonstrated that, even for T cells bearing identical T cell receptors, both clonal expansion and differentiation patterns are heterogeneous. As a consequence, individual naïve T lymphocytes contributed differentially to short- and long-term protection, as revealed by participation of their progeny during primary versus recall infections. The discordance in fate of individual naïve T cells argues against asymmetric division as a singular driver of CD8(+) T cell heterogeneity and demonstrates that reproducibility of CD8(+) T cell responses is achieved through population averaging.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
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Subgrupos de Linfocitos T
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Linfocitos T CD8-positivos
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Inmunidad Celular
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Memoria Inmunológica
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Listeriosis
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2013
Tipo del documento:
Article
País de afiliación:
Países Bajos