Cutaneous presentation of chronic lymphocytic leukemia as unique extramedullar involvement in a patient with normal peripheral blood lymphocyte count (monoclonal B-cell lymphocytosis).
J Cutan Pathol
; 40(8): 740-4, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23639136
ABSTRACT
Skin infiltration by chronic lymphocytic leukemia (CLL) is very rare and almost all reported cases occur in advanced stage. We report a patient with no relevant past medical history who presented with cutaneous erythematous plaques. A punch biopsy showed typical CLL morphologic and immunophenotypic features. Subsequent studies revealed a normal lymphocyte count in peripheral blood, and there was no evidence of lymphadenopathy or organomegaly. Flow cytometry demonstrated a clonal B-cell population both in the bone marrow and peripheral blood (1.60 × 10(9)/l) with a CLL phenotype, but it did not fulfill required criteria for CLL diagnosis. Without cutaneous involvement, this case should be classified as monoclonal B-cell lymphocytosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Linfocitos B
/
Leucemia Linfocítica Crónica de Células B
/
Linfocitosis
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
J Cutan Pathol
Año:
2013
Tipo del documento:
Article
País de afiliación:
España