Would the real human embryonic stem cell please stand up?
Bioessays
; 35(7): 632-8, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23653435
ABSTRACT
Embryonic stem cells (ESCs) are now classified into two types of pluripotency "naïve" and "primed" based upon their differing characteristics. Conventional human ESCs have much more in common with mouse epiblast stem cells and are now deemed to be primed. Naïve human ESCs that resemble mouse ESCs have recently been generated from their primed counterpart by cellular reprogramming. Isolation of naïve hESCs from human embryos has proven to be difficult. Is the inability to capture naïve hESCs the result of suboptimal derivation conditions or because they are so transient they cannot be "captured" in vitro? Prevailing evidence surrounding this issue are inconclusive and require additional human embryo research. However, negative public opinion regarding human embryo research, may make this an uphill battle. The solution may come from cellular reprogramming.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Embrionarias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioessays
Asunto de la revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá