Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia.
Clin Nephrol
; 79(6): 494-8, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23725649
ABSTRACT
A 25-year-old woman was admitted because of proteinuria. A renal biopsy showed mesangial/endocapillary proliferative glomerulonephritis with IgG2-κ deposits. Electron microscopy showed immune complex-type deposits. She also had Coombs-positive hemolytic anemia, anticardiolipin antibodies, and antinuclear antibodies. Middle-dose steroid therapy led to improvement of proteinuria and hemolytic anemia. Six years later, she developed crescentic glomerulonephritis with IgG2-κ deposits during pregnancy. Middle-dose steroid therapy improved renal dysfunction. This is an exceptional case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a recently described rare dysproteinemia-related glomerulonephritis, associated with autoimmune disease. This case also suggests that crescentic glomerulonephritis can be superimposed on PGNMID.
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Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Hematológicas del Embarazo
/
Inmunoglobulina G
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Glomerulonefritis Membranoproliferativa
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Factores Inmunológicos
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Anemia Hemolítica Autoinmune
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Clin Nephrol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón