Efficient synthesis and antioxidant evaluation of 2-aryl-3-(pyrimidin-2-yl)-thiazolidinones.
J Biochem Mol Toxicol
; 27(9): 445-50, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23798366
ABSTRACT
In the present study, we reported the efficient synthesis of 11 3-(pyrimidin-2-yl)-thiazolidinones in good yields using molecular sieve as the desiccant agent. In addition, we have evaluated the antioxidant capacity of the synthesized compounds by the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPHâ¢) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS(+â¢) ) radicals scavenging assay. Six compounds showed antioxidant activity towards DPPH⢠(EC50 between 16.13 and 49.94 µg/mL) and also demonstrated excellent activity regarding ABTS(+â¢) (TEAC 10.32-53.52). These results showed that compounds 3-(pyrimidin-2-yl)-thiazolidinones may be easily synthesized by a less expensive procedure and could be a good starting point to the development of new antioxidant compounds.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Tiazolidinas
/
Antioxidantes
Idioma:
En
Revista:
J Biochem Mol Toxicol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
TOXICOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil