Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.
Antimicrob Agents Chemother
; 57(9): 4559-61, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23817368
ABSTRACT
We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre- and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Fúngicas
/
Farmacorresistencia Fúngica
/
Candida glabrata
/
Equinocandinas
/
Candidemia
/
Glucosiltransferasas
/
Antifúngicos
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos