Proteostasis in complex dendrites.
Nat Rev Neurosci
; 14(9): 638-48, 2013 09.
Article
en En
| MEDLINE
| ID: mdl-23900412
ABSTRACT
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes â¼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage and plastic properties. The cell biological mechanisms that synthesize, modify, deliver and degrade dendritic and synaptic proteins are not well understood but appear to reflect unique solutions adapted to the particular morphology of neurons.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sinapsis
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Priones
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Compartimento Celular
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Dendritas
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Proteínas del Tejido Nervioso
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Neuronas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania