About sound science, stable isotope dilution, blasphemy and heresy.
Bioanalysis
; 5(16): 2015-21, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23937136
ABSTRACT
The molar ratio between an analyte and its equal labeled with stable isotope(s), used as a bioanalytical IS, is here suggested as an essential (and currently not commonly applied) validation parameter. This parameter, when calculated and measured, gives the possibility for the bioanalyst to compare calibration graphs and QC samples over time independently of added amount of IS. Additionally, when QC samples and calibration samples do not agree it is obvious to identify where the discrepancies are. Whether calibration samples are needed when this parameter is extensively and carefully validated and understood, is also discussed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ciencia
/
Técnicas de Dilución del Indicador
/
Pruebas con Sangre Seca
Idioma:
En
Revista:
Bioanalysis
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia