Fremy's salt-mediated oxidative addition. A new approach in the total synthesis of naturally dipetalolactone and its immunomodulatory activity.
Molecules
; 18(9): 11485-95, 2013 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-24043143
The structure of the natural dipyranocoumarin dipetalolactone has been confirmed by an unambiguous synthetic route from resorcinol. This sequence was initiated by a pyran ring formation step which introduced the 3-chloro-3-methylbut-1-yne moiety. Then, the expected product undergoes a Fremy's salt-meditated oxidative addition followed by ring closure to yield dipetalolactone. Dipetalolactone was also found to have immunological activity in a mouse carcinoma S180-bearing mice cell line.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cromonas
/
Factores Inmunológicos
/
Antineoplásicos
/
Compuestos Nitrosos
Límite:
Animals
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Egipto