Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.

Nyskohus, Laura S; Watson, Amanda J; Margison, Geoffrey P; Le Leu, Richard K; Kim, Susan W; Lockett, Trevor J; Head, Richard J; Young, Graeme P; Hu, Ying

Nyskohus, Laura S; Watson, Amanda J; Margison, Geoffrey P; Le Leu, Richard K; Kim, Susan W; Lockett, Trevor J; Head, Richard J; Young, Graeme P; Hu, Ying.

Afiliación

Nyskohus LS; Flinders Centre for Innovation in Cancer, Flinders University of South Australia, Australia.

Mutat Res Genet Toxicol Environ Mutagen ; 758(1-2): 80-6, 2013 Dec 12.

Article en En | MEDLINE | ID: mdl-24140386

Asunto(s)

Apoptosis/efectos de los fármacos; Azoximetano/toxicidad; Colon/efectos de los fármacos; Guanina/análogos & derivados; O(6)-Metilguanina-ADN Metiltransferasa/metabolismo; Animales; Colon/citología; Colon/metabolismo; Guanina/metabolismo; Ratas

Palabras clave

1,2-dimethylhydrazine; AOM; Apoptosis; Azoxymethane; CRC; Colon cancer; DMH; DNA repair; DSB; MGMT; O(6)-meG; O(6)-meG adduct; O(6)-methylguanine; O(6)-methylguanine DNA methyltransferase; azoxymethane; colorectal cancer; double-strand break

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azoximetano / Apoptosis / Colon / O(6)-Metilguanina-ADN Metiltransferasa / Guanina Límite: Animals Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Año: 2013 Tipo del documento: Article País de afiliación: Australia

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