Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.
Am J Hum Genet
; 93(6): 1143-50, 2013 Dec 05.
Article
en En
| MEDLINE
| ID: mdl-24290379
ABSTRACT
Foveal hypoplasia and optic nerve misrouting are developmental defects of the visual pathway and only co-occur in connection with albinism; to date, they have only been associated with defects in the melanin-biosynthesis pathway. Here, we report that these defects can occur independently of albinism in people with recessive mutations in the putative glutamine transporter gene SLC38A8. Nine different mutations were identified in seven Asian and European families. Using morpholino-mediated ablation of Slc38a8 in medaka fish, we confirmed that pigmentation is unaffected by loss of SLC38A8. Furthermore, by undertaking an association study with SNPs at the SLC38A8 locus, we showed that common variants within this gene modestly affect foveal thickness in the general population. This study reveals a melanin-independent component underpinning the development of the visual pathway that requires a functional role for SLC38A8.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nervio Óptico
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Albinismo
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Sistemas de Transporte de Aminoácidos Neutros
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Fóvea Central
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Genes Recesivos
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Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Am J Hum Genet
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido