[Determination of proliferation in breast cancer by immunohistochemical detection of Ki-67]. / Proliferationsbestimmung beim Mammakarzinom durch den immunhistochemischen Nachweis von Ki-67.
Pathologe
; 35(1): 54-60, 2014 Feb.
Article
en De
| MEDLINE
| ID: mdl-24414612
ABSTRACT
Gene expression profiling has demonstrated the prognostic relevance of genes associated with proliferation in breast cancer. The immunohistochemical marker Ki-67 enables routine assessment of proliferation activity in pathology. In a number of retrospective but only few prospective studies the prognostic relevance of Ki-67 in breast cancer could be shown. Although there is no standardized approach with regard to which area of a histological section and how many cells should be counted in a quantitative or semiquantitative fashion as well as to the threshold, Ki-67 is broadly applied in breast pathology. This can be explained by the good reproducibility of the degree of proliferation assessed by Ki-67, at least in the low and high ranges, the possibility to substantiate grading and better practicability in core biopsies in comparison to mitotic counting. In neoadjuvant therapy of hormone receptor positive breast cancer, Ki-67 can probably predict the efficacy of pure hormone receptor blockade without chemotherapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Biomarcadores de Tumor
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Antígeno Ki-67
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Carcinoma Ductal
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Proliferación Celular
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
Idioma:
De
Revista:
Pathologe
Año:
2014
Tipo del documento:
Article