S-1-based combination therapy vs S-1 monotherapy in advanced gastric cancer: a meta-analysis.
World J Gastroenterol
; 20(1): 310-8, 2014 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-24415887
ABSTRACT
AIM:
To assess the efficacy and safety of combination therapy based on S-1, a novel oral fluoropyrimidine, vs S-1 monotherapy in advanced gastric cancer (AGC).METHODS:
We searched PubMed, EMBASE and the Cochrane Library for eligible studies published before March 2013. Our analysis identified four randomized controlled trials involving 790 participants with AGC. The outcome measures were overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and grade 3-4 adverse events.RESULTS:
Meta-analysis showed that S-1-based combination therapy significantly improved OS (HR = 0.77, 95%CI 0.66-0.91, P = 0.002), PFS (HR = 0.58, 95%CI 0.46-0.72, P = 0.000) and ORR (OR = 2.23, 95%CI 1.54-3.21, P = 0.000). Sensitivity analysis further confirmed this association. Lower incidence of grade 3-4 leucopenia (OR = 4.06, 95%CI 2.11-7.81), neutropenia (OR = 3.94, 95%CI 2.1-7.81) and diarrhea (OR = 2.41, 95%CI 1.31-4.44) was observed in patients with S-1 monotherapy.CONCLUSION:
S-1-based combination therapy is superior to S-1 monotherapy in terms of OS, PFS and ORR. S-1 monotherapy is associated with less toxicity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ácido Oxónico
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Neoplasias Gástricas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Tegafur
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
World J Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China